To explore ways to help prevent hair loss caused by an autoimmune
attack on the follicles, researchers at Columbia University made a
fortuitous discovery that could have implications for the fight against
all baldness.
The equipment was watching treating a condition known as alopecia areata with drugs that inhibit a family of enzymes found in hair follicles known as Janus kinase, or JAK. male pattern baldnessLast year, Angela M. Christiano, professor of dermatology and genetics and development, and colleagues reported JAK inhibitors were effective in closing the signal that causes the autoimmune attack. They also found that when the drug is administered orally, helped restore hair growth in some people with alopecia areata.
female pattern baldnessNow, however, the team reported that inhibitors of JAK if applied directly to the skin can promote the "rapid and robust growth of hair," according to Columbia University Medical Center. In fact, in mouse studies, after only three weeks of treatment, the rodents had grown almost all his hair. The drugs also produce human hair follicles grown in the laboratory. This latest work appears in the journal Science Advances.hair-loss.jpg
The equipment was watching treating a condition known as alopecia areata with drugs that inhibit a family of enzymes found in hair follicles known as Janus kinase, or JAK. male pattern baldnessLast year, Angela M. Christiano, professor of dermatology and genetics and development, and colleagues reported JAK inhibitors were effective in closing the signal that causes the autoimmune attack. They also found that when the drug is administered orally, helped restore hair growth in some people with alopecia areata.
female pattern baldnessNow, however, the team reported that inhibitors of JAK if applied directly to the skin can promote the "rapid and robust growth of hair," according to Columbia University Medical Center. In fact, in mouse studies, after only three weeks of treatment, the rodents had grown almost all his hair. The drugs also produce human hair follicles grown in the laboratory. This latest work appears in the journal Science Advances.hair-loss.jpg
The mouse in the middle and right mouse had half of their treaties with the two JAK inhibitors currently FDA approved bodies. All returned them to grow hair.
"Not many compounds that can push hair follicles growth cycle so quickly," Christiano said in the report. "Some topical agents induce strands of hair here and there after a few weeks, but very few compounds have this powerful effect so quickly."
Hair follicles typically change between being active and being dormant. Columbia researchers found that the drugs affect the follicles, forcing them to be in an "on" (or on) position.
Christiano was careful to note that the researchers do not yet know whether the treatment will work in humans in the treatment of baldness, which causes hair loss in both men and women as they age.
"What we have found is promising, although we have not yet proved to be a cure for baldness," he said. "We must do more work to test whether JAK inhibitors can induce hair growth in humans using formulations made especially for the scalp".
hair loss in men hair loss in women This work is currently being carried out by the team and if successful, could lead to a product to help men and women to fight baldness and thinning hair.Related Articles
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